MicroRNA-34a activation in tuberous sclerosis complex during early brain development may lead to impaired corticogenesis.
Anatoly KorotkovNam Suk SimMark J LuinenburgJasper J AninkJackelien van ScheppingenTill S ZimmerAnika BongaartsDiede W M BroekaartCaroline MijnsbergenFloor E JansenWim Van HeckeWim G M SplietPeter C van RijenMartha FeuchtJohannes A HainfellnerPavel KršekJosef ZamecnikPeter B CrinoKatarzyna KotulskaLieven LagaeAnna C JansenDavid J KwiatkowskiSergiusz JozwiakPaolo CuratoloAngelika MühlebnerJeong Ho LeeJames D MillsErwin Alexander van VlietEleonora M A AronicaPublished in: Neuropathology and applied neurobiology (2021)
MicroRNA-34a is most highly overexpressed in tubers during foetal and early postnatal brain development. miR-34a can negatively regulate mTORC1; however, it may also contribute to abnormal corticogenesis in TSC.