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Profiling the microRNA signature of the peripheral sensory ganglia in experimental autoimmune encephalomyelitis (EAE).

Timothy N FriedmanMuhammad Saad YousufAna CatuneanuMansi DesaiCamille A JuźwikAlyson E FournierBradley J Kerr
Published in: Journal of neuroinflammation (2019)
This study provides evidence that females are uniquely affected by MOG35-55-EAE and that this difference may result from additional signaling not present in the male. The altered transcriptome of females correlates with other studies finding hyperactivity of pain-sensing neurons and suggests underlying sex-specific pathways for neuropathic pain.
Keyphrases
  • neuropathic pain
  • spinal cord
  • spinal cord injury
  • single cell
  • gene expression
  • chronic pain
  • rna seq
  • genome wide
  • chemotherapy induced
  • postoperative pain