TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer.

Aditi S Khatpe Rebecca C Dirks Poornima Bhat-Nakshatri Henry Elmer Mang Katie Batic Sarah Swiezy Jacob Olson Xi Rao Yue Wang Hiromi Tanaka Sheng Liu Jun Wan Duojiao Chen Yunlong Liu Fang Fang Sandra Althouse Emily Hulsey Maggie M Granatir Rebekah Addison Constance J Temm George E Sandusky Audrey Lee-Gosselin Kenneth P Nephew Kathy D Miller Harikrishna Nakshatri

Published in: Cancer research (2023)

The chr.8q24.3 amplicon-resident gene TONSL is upregulated during the initial steps of tumorigenesis to support neoplastic transformation by increasing DNA repair and represents a potential therapeutic target for treating breast cancer.

Keyphrases

dna repair
dna damage
dna damage response
genome wide
patient safety
oxidative stress
human health
gene expression
risk assessment