Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort.
Inge M M LakemanMar Rodríguez-GirondoAndrew LeeRikje RuiterBruno H StrickerSara R A WijnantMaryam KavousiAntonis C AntoniouMarjanka K SchmidtAndré G UitterlindenJeroen van RooijPeter DevileePublished in: Genetics in medicine : official journal of the American College of Medical Genetics (2020)
The effect size of the PRS313 is highly reproducible in the Dutch population. Our results validate the BOADICEA v5 model for BC risk assessment in the Dutch general population.
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