Inhibition of STAT3 prevents bone metastatic progression of prostate cancer in vivo.

Malin Hagberg ThulinJorma MäättäAnna LinderSimona SterbovaClaes OhlssonJan-Erik DamberAnders WidmarkEmma Persson

Published in: The Prostate (2021)

Inhibition of STAT3 activity disrupts the bone metastatic niche and targets both the skeletal establishment of PC and advanced bone metastatic CRPC in mice, suggesting STAT3 as a candidate for molecular targeted therapies of skeletal metastatic disease.

Keyphrases

squamous cell carcinoma
small cell lung cancer
prostate cancer
bone mineral density
cell proliferation
soft tissue
bone loss
type diabetes
metabolic syndrome
postmenopausal women
mouse model
body composition
single molecule
high fat diet induced