IGF-Binding Proteins, Adiponectin, and Survival in Metastatic Colorectal Cancer: Results From CALGB (Alliance)/SWOG 80405.
Brendan J GuercioSui ZhangFang-Shu OuAlan P VenookDonna NiedzwieckiHeinz-Josef LenzFederico InnocentiMichael N PollakAndrew B NixonBrian C MullenBert H O'NeilJames E ShawBlase N PoliteAl Bowen BensonJames N AtkinsRichard M GoldbergJustin C BrownEileen M O'ReillyRobert J MayerCharles David BlankeCharles S FuchsJeffrey A MeyerhardtPublished in: JNCI cancer spectrum (2020)
Among patients with mCRC, high plasma IGFBP-3 and low IGFBP-7 were associated with longer OS and PFS. Extreme levels of adiponectin were associated with shorter PFS. These findings suggest potential avenues for prognostic and therapeutic innovation.