Influence of previous Zika virus infection on acute dengue episode.

Cassia F EstofoleteAlice F VersianiFernanda S DouradoBruno H G A MilhimCarolina C PaccaGislaine C D SilvaNathalia ZiniBarbara F Dos SantosFlora A GandolfiNatalia F B MistrãoPedro H C GarciaRodrigo S RochaLee GehrkeIrene BoschRafael E MarquesMauro M TeixeiraFlavio G da FonsecaNikos VasilakisMauricio Lacerda Nogueira

Published in: PLoS neglected tropical diseases (2023)

Our findings suggest that previous Zika infection may represent a risk factor for subsequent severe dengue disease, but we did not find evidence of antibody-dependent enhancement (higher viral titer or pro-inflammatory cytokine overexpression) contributing to exacerbation of the subsequent dengue infection.

Keyphrases

zika virus
aedes aegypti
dengue virus
respiratory failure
liver failure
chronic obstructive pulmonary disease
sars cov
cell proliferation
early onset
transcription factor