Triglyceride Glucose-Waist Circumference Better Predicts Coronary Calcium Progression Compared with Other Indices of Insulin Resistance: A Longitudinal Observational Study.
Yun Kyung ChoJiwoo LeeHwi Seung KimEun Hee KimMin Jung LeeDong Hyun YangJoon Won KangChang Hee JungJoong-Yeol ParkHong-Kyu KimWoo Je LeePublished in: Journal of clinical medicine (2020)
The triglyceride glucose (TyG) index, a product of triglyceride and fasting glucose, is a reliable marker for insulin resistance. We aimed to investigate the association between the TyG-related markers and coronary artery calcification (CAC) progression. We enrolled 1145 asymptomatic participants who underwent repeated CAC score measurements during routine health examinations. Homeostasis model assessment of insulin resistance (HOMA-IR), TyG index, TyG-BMI (body mass index), and TyG-WC (waist circumference) were calculated. Progression of CAC was defined as (1) incident CAC in a CAC-free population, or an (2) increase of ≥2.5 units between the baseline and final square root of the CAC scores in participants with detectable CAC. According to the quartiles of parameters, we stratified the subjects into four groups. The prevalence of progression increased with the TyG-WC quartile (15.0%, 24.1%, 31.0%, and 32.2% for each of the groups; p < 0.001). The multivariate-adjusted odds ratio (95% confidence interval) for CAC score progression was 1.66 (1.01-2.77) when the highest and lowest TyG-WC index quartiles were compared. Furthermore, the predictability of TyG-WC for CAC progression was better than the other indices in terms of the area under the curve. The TyG-WC index predicted CAC progression better than other indices and could be a potential marker of future coronary atherosclerosis.
Keyphrases
- insulin resistance
- coronary artery
- body mass index
- adipose tissue
- blood glucose
- cardiovascular disease
- public health
- metabolic syndrome
- type diabetes
- coronary artery disease
- high fat diet
- skeletal muscle
- mental health
- risk factors
- chronic kidney disease
- blood pressure
- pulmonary artery
- clinical practice
- pulmonary hypertension
- social media
- glycemic control
- human health
- low density lipoprotein
- climate change
- aortic stenosis