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Nuclear staining for pan-Trk by immunohistochemistry is highly specific for secretory carcinoma of breast: pan-Trk in various subtypes of breast carcinoma.

Qiqi YeHui ChenCody HanYan PengXiao HuangHongxia SunYun WuConstance T AlbarracinLavinia P MiddletonAysegul A SahinLei HuoQingqing Ding
Published in: Journal of clinical pathology (2023)
Our results indicate that pan-Trk nuclear staining is highly specific for SCB. In low-grade to intermediate-grade IBCs that share histological features with SCB, adding pan-Trk to a routing panel of estrogen receptor/progesterone receptor/HER2 is highly diagnostic. Our results also support using pan-Trk IHC to differentiate SCB from its triple-negative histological mimickers, such as adenoid cystic carcinoma, matrix-producing carcinoma, apocrine carcinoma and acinic cell carcinoma.
Keyphrases
  • estrogen receptor
  • low grade
  • flow cytometry