Antibiotics affect the pharmacokinetics of n-butylphthalide in vivo by altering the intestinal microbiota.

Xiangchen LiXiaoli GuoYixin LiuFeifei RenShan LiXiuling YangJian LiuZhiqing Zhang

Published in: PloS one (2024)

Antibiotic treatment could affect the intestinal microbiota, decrease CYP3A1 mRNA and protein expressions and increase NBP exposure in vivo by inhibiting pathways related to NBP metabolism.

Keyphrases

binding protein
signaling pathway
small molecule
combination therapy