Genetics of Familial Combined Hyperlipidemia (FCHL) Disorder: An Update.
Eskandar TaghizadehNajmeh FarahaniRajab MardaniForough TaheriHassan TaghizadehSeyed Mohammad GheibihayatPublished in: Biochemical genetics (2021)
Familial combined hyperlipidemia (FCHL) is one of the most common familial lipoprotein disorders of the lipoproteins, with a prevalence of 0.5% to 2% in different populations. About 10% of these patients suffer from cardiovascular disease and this number is increased by up to 11.3% in the young survivors of myocardial infarction and by 40% among all the survivors of myocardial infarction. Although initially thought to be that FCHL has an inheritance pattern of monogenic, the disease's etiology is still not fully understood and it appears that FCHL has a complex pattern related to genetic variants, environmental factors, and lifestyles. Two strategies have been used to identify its complex genetic background: candidate gene and the linkage approach, which have yielded an extensive list of genes associated with FCHL with a variable degree of scientific evidence. Until now, more than 30 different genetic variants have been identified related to FCHL. In this study, we aimed to review the individual genes that have been described in FCHL and how these genes and variants can be related to the current concept of metabolic pathways resulting in familial combined hyperlipidemia.
Keyphrases
- genome wide
- cardiovascular disease
- early onset
- copy number
- end stage renal disease
- high fat diet
- heart failure
- young adults
- left ventricular
- chronic kidney disease
- ejection fraction
- dna methylation
- newly diagnosed
- type diabetes
- prognostic factors
- peritoneal dialysis
- gene expression
- coronary artery disease
- metabolic syndrome
- atrial fibrillation
- patient reported outcomes
- transcription factor
- men who have sex with men
- high fat diet induced
- genetic diversity
- patient reported
- high density