Regulatory effects of a novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae on mice immune cells.
Jing-Yun XuXiaoBin GuYue XieRan HeJing XuLang XiongXueRong PengGuangyou YangPublished in: Parasites & vectors (2022)
rBsCPI-1 can transduce regulatory signals into immune cells by activating the TLR2/4-NF-κB/MAPK signaling pathway, having a certain regulatory effect on the physiological activities. Meanwhile, rBsCPI-1 can maintain the immune response in a balance by limiting the over-activation of the TLRs signaling pathway and thus contributes to B. schroederi immune evasion.
Keyphrases
- signaling pathway
- pi k akt
- immune response
- transcription factor
- induced apoptosis
- epithelial mesenchymal transition
- toll like receptor
- oxidative stress
- type diabetes
- nuclear factor
- metabolic syndrome
- adipose tissue
- skeletal muscle
- high fat diet induced
- living cells
- fluorescent probe
- endoplasmic reticulum stress
- cell proliferation
- aedes aegypti
- single molecule