Non-Coding RNAs: Novel Players in Insulin Resistance and Related Diseases.
Caterina FormichiLaura NigiGiuseppina Emanuela GriecoCarla MaccoraDaniela FignaniNoemi BruscoGiada LicataGuido SebastianiFrancesco DottaPublished in: International journal of molecular sciences (2021)
The rising prevalence of metabolic diseases related to insulin resistance (IR) have stressed the urgent need of accurate and applicable tools for early diagnosis and treatment. In the last decade, non-coding RNAs (ncRNAs) have gained growing interest because of their potential role in IR modulation. NcRNAs are variable-length transcripts which are not translated into proteins but are involved in gene expression regulation. Thanks to their stability and easy detection in biological fluids, ncRNAs have been investigated as promising diagnostic and therapeutic markers in metabolic diseases, such as type 2 diabetes mellitus (T2D), obesity and non-alcoholic fatty liver disease (NAFLD). Here we review the emerging role of ncRNAs in the development of IR and related diseases such as obesity, T2D and NAFLD, and summarize current evidence concerning their potential clinical application.
Keyphrases
- insulin resistance
- metabolic syndrome
- gene expression
- type diabetes
- high fat diet induced
- adipose tissue
- high fat diet
- skeletal muscle
- polycystic ovary syndrome
- weight loss
- dna methylation
- glycemic control
- weight gain
- risk factors
- high resolution
- physical activity
- cardiovascular risk factors
- risk assessment
- quantum dots
- sensitive detection