Discordance in acute gastrointestinal toxicity between synchrotron-based proton and linac-based electron ultra-high dose rate irradiation.

Kevin LiuUwe TittNolan EsplenLuke ConnellElise KonradssonMing YangXiaochun WangTakeshi TakaokaZiyi LiAlbert C KoongDevarati MitraRadhe MohanBilly W LooSteven H LinEmil Schüler

Published in: bioRxiv : the preprint server for biology (2024)

Our findings are consistent with an increase in RIGIT after synchrotron-based pFLASH versus pCONV. This negative proton-specific FLASH effect versus linac-based electron irradiation underscores the importance of understanding the physical and biological factors that will allow safe and effective clinical translation.

Keyphrases

high dose
electron transfer
liver failure
low dose
mental health
physical activity
high resolution
oxidative stress
respiratory failure
stem cell transplantation
intensive care unit
drug induced
solar cells
aortic dissection
radiation therapy
mechanical ventilation