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Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma.

Jiawen YangJames T LimPaul VictorChen ChenHunain KhwajaRick G SchnellmannDenise J RoePrafulla C GokhaleJames A DecaprioMegha Padi
Published in: bioRxiv : the preprint server for biology (2023)
Our study sheds light on the role of the WNT signaling pathway in MCC transformation and characterizes pyrvinium pamoate as a potent anti-tumor reagent that targets multiple vulnerabilities of MCC.
Keyphrases
  • signaling pathway
  • stem cells
  • pi k akt
  • epithelial mesenchymal transition
  • anti inflammatory
  • oxidative stress