Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma.
Jiawen YangJames T LimPaul VictorChen ChenHunain KhwajaRick G SchnellmannDenise J RoePrafulla C GokhaleJames A DecaprioMegha PadiPublished in: bioRxiv : the preprint server for biology (2023)
Our study sheds light on the role of the WNT signaling pathway in MCC transformation and characterizes pyrvinium pamoate as a potent anti-tumor reagent that targets multiple vulnerabilities of MCC.