Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma.

Jiawen YangJames T LimPaul VictorChen ChenHunain KhwajaRick G SchnellmannDenise J RoePrafulla C GokhaleJames A DecaprioMegha Padi

Published in: bioRxiv : the preprint server for biology (2023)

Our study sheds light on the role of the WNT signaling pathway in MCC transformation and characterizes pyrvinium pamoate as a potent anti-tumor reagent that targets multiple vulnerabilities of MCC.

Keyphrases

signaling pathway
stem cells
pi k akt
epithelial mesenchymal transition
anti inflammatory
oxidative stress