The new complement inhibitor CRIg/FH ameliorates lupus nephritis in lupus-prone MRL/lpr mice.

Yu ShiWen YaoLi SunGuomin LiHaimei LiuPeipei DingWeiguo HuHong Xu

Published in: BMC nephrology (2019)

Our results showed that the complement inhibitor CRIg/FH can protect MRL/lpr mice from lupus nephropathy by preserving renal function and glomerulus complement activation. Our findings support the positive effect of complement inhibitors in the treatment of lupus nephropathy.

Keyphrases

systemic lupus erythematosus
disease activity
high fat diet induced
rheumatoid arthritis
type diabetes
metabolic syndrome
insulin resistance
combination therapy
adipose tissue
wild type