A Modified Nucleoside 6-Thio-2'-Deoxyguanosine Exhibits Antitumor Activity in Gliomas.

Shengnan YuShiyou WeiMilan R Savani Xiang LinKuang DuIlgen Mender Silvia SiteniThemistoklis VasilopoulosZachary J ReitmanYin KuDi WuHao LiuMeng TianYaohui ChenMarilyne LabrieCasey M CharbonneauEric SugarmanMichelle BowieSeethalakshmi HariharanMatthew S Waitkus Wen Jiang Roger E McLendon Edward Pan Mustafa Khasraw Kyle M WalshYiling LuMeenhard HerlynGordon B MillsUtz HerbigZhi WeiStephen T KeirKeith FlahertyLun-Xu LiuKongming WuJerry W ShayKalil G Abdullah Gao ZhangDavid M Ashley

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

The current study established the therapeutic role of THIO in primary and recurrent gliomas and revealed the acute induction of telomeric DNA damage as a primary antitumor mechanism of THIO in gliomas.

Keyphrases

high grade
dna damage
liver failure
oxidative stress
dna repair
respiratory failure
single cell
drug induced
dna damage response