Impact of incorporating ABCB1 and CYP4F2 polymorphisms in a pharmacogenetics-guided warfarin dosing algorithm for the Brazilian population.

Letícia C TavaresNubia E DuarteLeiliane R MarcattoRenata A G SoaresJose E KriegerAlexandre C PereiraPaulo Caleb Júnior Lima Santos

Published in: European journal of clinical pharmacology (2018)

Although our study indicates that the contribution of the combined ABCB1 and CYP4F2 genotypes in explaining the overall variability in warfarin dose is not very large, we demonstrated that these pharmacogenomic data are statistically significant. However, the clinical relevance and cost-effective impact of incorporating additional variants in warfarin dosing algorithms should be carefully evaluated.

Keyphrases

atrial fibrillation
direct oral anticoagulants
venous thromboembolism
machine learning
oral anticoagulants
deep learning
electronic health record
big data
copy number
gene expression
clinical decision support