CD73 alleviates GSDMD-mediated microglia pyroptosis in spinal cord injury through PI3K/AKT/Foxo1 signaling.

Shun XuJin WangJunjie ZhongMinghao ShaoJianyuan JiangJian SongWei ZhuFan ZhangHaocheng XuGuangyu XuYuxuan ZhangXiaosheng MaFeizhou Lu

Published in: Clinical and translational medicine (2021)

Our data reveal a novel function of CD73 on microglia pyroptosis, suggesting a unique therapeutic opportunity for mitigating the disease process in SCI.

Keyphrases

pi k akt
spinal cord injury
signaling pathway
neuropathic pain
cell proliferation
cell cycle arrest
inflammatory response
nlrp inflammasome
spinal cord
nk cells
electronic health record
big data
genome wide
transcription factor
single cell
mouse model
machine learning
deep learning