Design, Synthesis, Docking Study, and Biological Evaluation of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbohydrazide Derivatives as Anti-HIV-1 and Antibacterial Agents.
Omid AbdollahiArash MahboubiZahra HajimahdiAfshin ZarghiPublished in: Iranian journal of pharmaceutical research : IJPR (2022)
According to the docking analyses, the orientation of the designed scaffold in the active site of integrase is similar to the other inhibitors of the HIV integrase and can be regarded as an acceptable template for further structural modification to improve potencies.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- molecular dynamics
- hepatitis c virus
- molecular dynamics simulations
- hiv aids
- men who have sex with men
- protein protein
- south africa
- small molecule
- mass spectrometry
- tissue engineering
- molecularly imprinted
- high resolution
- wound healing