SERPINA12 promotes the tumorigenic capacity of hepatocellular carcinoma stem cells through hyperactivation of AKT/ β-catenin signaling.

Huajian YuLei ZhouJane Hc LoongKa-Hei LamTin-Lok WongKai-Yu NgMan TongVictor Ws MaYanyan WangXiang ZhangTerence K LeeJing-Ping YunJun YuStephianie Ma

Published in: Hepatology (Baltimore, Md.) (2023)

Collectively, our findings revealed that SERPINA12 is preferentially overexpressed in epithelial HCC CD133+cells and is a key contributor to HCC initiation and progression by driving an AKT/β-catenin feed-forward loop.

Keyphrases

stem cells
cell proliferation
signaling pathway
induced apoptosis
cell cycle arrest
epithelial mesenchymal transition
transcription factor
single cell
cell death
cell therapy
nk cells