Inhibition of eIF2α Dephosphorylation Protects Hepatocytes from Apoptosis by Alleviating ER Stress in Acute Liver Injury.

Yong-Jing TangHuan ChenYu YiGui-Mei ChenFang-Wan YangYing LiRen-Dong TianWen-Ge HuangQi-Jiao ChengYi-Huai He

Published in: BioMed research international (2020)

eIF2α phosphorylation is one of the mechanisms employed by ER stress for restoring cellular homeostasis. Inhibition of eIF2α dephosphorylation mitigates hepatocyte apoptosis by alleviating ER stress in acute liver injuries.

Keyphrases

liver injury
drug induced
oxidative stress
endoplasmic reticulum stress
cell cycle arrest
liver failure
cell death
respiratory failure
aortic dissection
radiation induced
radiation therapy
hepatitis b virus
intensive care unit
acute respiratory distress syndrome
pi k akt