Cyclooxygenase-2 activates EGFR-ERK1/2 pathway via PGE2-mediated ADAM-17 signaling in testosterone-induced benign prostatic hyperplasia.
Mohammed E Abo-El FetohMaha M Abdel-FattahWafaa R MohamedLaila A A RamadanHassan AfifyPublished in: Inflammopharmacology (2022)
COX-2 stimulates the ERK1/2 pathway via PGE2-ADAM-17-catalyzed shedding of TGF-α in testosterone-induced BPH. The results indicate a functional correlation between inflammation and hyperplasia in BPH.
Keyphrases
- benign prostatic hyperplasia
- lower urinary tract symptoms
- high glucose
- signaling pathway
- diabetic rats
- small cell lung cancer
- cell proliferation
- oxidative stress
- replacement therapy
- pi k akt
- epidermal growth factor receptor
- transforming growth factor
- room temperature
- tyrosine kinase
- epithelial mesenchymal transition
- stress induced