Visualization of Epidermal Reservoir Formation from Topical Diclofenac Gels by Raman Spectroscopy.

Qihong Zhang Carol R FlachRichard MendelsohnLeanne PageSusan WhitsonMila Boncheva Bettex

Published in: Journal of pain research (2020)

The Raman images evidenced that the studied topical gels deliver diclofenac through the stratum corneum skin barrier and form a drug depot localized in the epidermis. The data are in line with earlier clinical findings that this depot acts like a true reservoir and enables sustained drug release.

Keyphrases

raman spectroscopy
drug release
wound healing
drug delivery
water quality
deep learning
electronic health record
convolutional neural network
optical coherence tomography
big data
adverse drug
artificial intelligence