SLy2-deficiency promotes B-1 cell immunity and triggers enhanced production of IgM and IgG2 antibodies against pneumococcal vaccine.
Jennifer JaufmannLeyla TümenFee SchmittDaniel SchällMax von HollebenSandra Beer-HammerPublished in: Immunity, inflammation and disease (2020)
Our results reveal reinforced specific antibody responses towards pneumococcal polysaccharides and enhanced IgG2 secretion as a consequence of SLy2 deficiency, which could be relevant to the development of more efficient vaccines.