Poly(methylmethacrylate-co-dimethyl acrylamide)-silver nanocomposite prevents biofilm formation in medical devices.
Fernanda B PerasoliLuan S B SilvaBruna I C FigueiredoIsabelle C PintoLorrane J F AmaroJuliana C S Almeida BastosSimone P CarneiroVânia P R AraújoFelipe R G BeatoAna P M BarbozaLuiz F M TeixeiraMaurice P GallagherMark BradleySeshasailam VenkateswaranOrlando David Henrique Dos SantosPublished in: Nanomedicine (London, England) (2024)
Aim: To investigate whether medical devices coated with a synthesized nanocomposite of poly(methylmethacrylate-co-dimethyl acrylamide) (PMMDMA) and silver nanoparticles (AgNPs) could improve their antibiofilm and antimicrobial activities. We also investigated the nanocomposite's safety. Materials & methods: The nanocomposite was synthesized and characterized using analytical techniques. Medical devices coated with the nanocomposite were evaluated for bacterial adhesion and hemolytic activity in vitro . Results: The nanocomposite formation was demonstrated with the incorporation of AgNPs into the polymer matrix. The nanocomposite proved to be nonhemolytic and significantly inhibited bacterial biofilm formation. Conclusion: The PMMDMA-AgNPs nanocomposite was more effective in preventing biofilm formation than PMMDMA alone and is a promising strategy for coating medical devices and reducing mortality due to hospital-acquired infections.
Keyphrases
- biofilm formation
- reduced graphene oxide
- silver nanoparticles
- staphylococcus aureus
- pseudomonas aeruginosa
- candida albicans
- quantum dots
- escherichia coli
- carbon nanotubes
- solid phase extraction
- visible light
- gold nanoparticles
- healthcare
- aqueous solution
- emergency department
- cystic fibrosis
- type diabetes
- cardiovascular disease
- cardiovascular events
- mass spectrometry
- high resolution
- tandem mass spectrometry
- atomic force microscopy