The Role of Pathological Method and Clearance Definition for the Evaluation of Margin Status after Pancreatoduodenectomy for Periampullary Cancer. Results of a Multicenter Prospective Randomized Trial.
Gennaro NappoDomenico BorzomatiAlessandro ZerbiPaola SpaggiariUgo BoggiDaniela CampaniSławomir MrowiecŁukasz LiszkaAlessandro CoppolaMichela AmatoTommasangelo PetittiFabio VistoliMarco MontorsiGiuseppe PerroneRoberto CoppolaDamiano CaputoPublished in: Cancers (2021)
The 1 mm clearance is the most effective factor in determining the R1 rate after PD. However, the pathological method is crucial to accurately evaluate its prognostic role: only R1 resections obtained with the adoption of LEEPP seem to significantly affect prognosis.