Association of polymorphisms in TNF-α, IL-1β, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?

GSTM and GSTT deletion polymorphisms, as well as TNFα (-308 G/A) SNP, are associated with increased risk, whereas IL-1β (-511 C/T) polymorphism decreases the risk of AP development. GSTT and TNFα polymorphisms also appear to modulate the risk of EBV infection in Serbian patients with AP.