A mucus production programme promotes classical pancreatic ductal adenocarcinoma.
Claudia TonelliGeorgi N YordanovYuan HaoAstrid DeschênesJuliene HindsPascal BelleauOlaf KlingbeilErin BrosnanAbhishek DoshiYoungkyu ParkRalph H HrubanChristopher R VakocAlexander DobinJonathan PreallDavid A TuvesonPublished in: Gut (2024)
Our findings expand our understanding of the transcriptional programmes active in precancerous lesions and PDAs of classical differentiation, determine the regulators of mucus production as specific vulnerabilities in these cell states and reveal phenotype switching as a response mechanism to inactivation of differentiation states determinants.