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Thrombin-targeted screening of anticoagulant active components from Polygonum amplexicaule D. Don var. sinense Forb by affinity ultrafiltration coupled with UPLC-Q-TOF-MS.

Shiyi HuangXiangchang HeChencun HuangWeihe HeHongqing ZhaoJie DaiGuangming Xu
Published in: Phytochemical analysis : PCA (2024)
A method system based on AUF-UPLC-Q-TOF-MS, molecular docking and in vivo and in vitro experiments also provided a powerful tool for further exploration of anticoagulant active components in PAF.
Keyphrases
  • molecular docking
  • atrial fibrillation
  • venous thromboembolism
  • molecular dynamics simulations
  • simultaneous determination
  • cancer therapy