Epigenetic Link Between Statin Therapy and Type 2 Diabetes.
Carolina Ochoa-RosalesEliana Portilla-FernandezJana NanoRory WilsonBenjamin LehnePashupati P MishraXu GaoMohsen GhanbariOscar L Rueda-OchoaDiana Juvinao-QuinteroMarie LohWeihua ZhangJaspal S KoonerHans J GrabeStephan B FelixBen SchöttkerYan ZhangChristian GiegerMartina Müller-NurasyidMargit HeierAnnette PetersTerho LehtimäkiAlexander TeumerHermann BrennerMelanie WaldenbergerM Arfan IkramJoyce B J van MeursOscar H FrancoTrudy G VoortmanJohn ChambersBruno H Ch StrickerTaulant MukaPublished in: Diabetes care (2020)
This study sheds light on potential mechanisms linking statins with type 2 diabetes risk, providing evidence on DNAm partially mediating statins' effects on insulin traits. Further efforts shall disentangle the molecular mechanisms through which statins may induce DNAm changes, potentially leading to ABCG1 epigenetic regulation.