Concurrent Definitive Immunoradiotherapy for Patients with Stage III-IV Head and Neck Cancer and Cisplatin Contraindication.
Jared WeissSiddharth ShethAllision M DealJuneko E Grilley OlsonSamip PatelTrevor G HackmanJeffrey M BlumbergThomas J GallowayShetal PatelAdam M ZanationColette J ShenDavid Neil HayesChristopher HilliardRanee MehraKaren P McKinnonHsing-Hui WangMark Christian WeisslerJessica R BaumanBhishamjit S CheraBenjamin G VincentPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Pembrolizumab and radiotherapy is efficacious in LA-HNSCC and should be evaluated in a randomized trial. The observed changes in B-cell markers deserve further study both as potential biomarkers and as therapeutic targets.