An SOS Regulon under Control of a Noncanonical LexA-Binding Motif in the Betaproteobacteria.
Neus Sanchez-AlberolaSusana CampoyDavid EmersonJordi BarbéIvan ErillPublished in: Journal of bacteriology (2015)
Understanding the evolution of transcriptional systems enables us to address important questions in microbiology, such as the emergence and transfer potential of different regulatory systems to regulate virulence or mediate responses to stress. The results reported here constitute the first characterization of a noncanonical LexA protein regulating a standard SOS regulon. This is significant because it illustrates how a complex transcriptional program can be put under the control of a novel transcriptional regulator. Our results also reveal a substantial degree of plasticity in the LexA recognition domain, raising intriguing questions about the space of protein-DNA interfaces and the specific evolutionary constrains faced by these elements.