Ca2+tapulting HSCs into action.

Amélie Valérie Guitart Andrew J Finch Kamil R Kranc

Published in: The Journal of experimental medicine (2018)

In this issue of JEM, Umemoto et al. (https://doi.org/10.1084/jem.20180421) demonstrate that calcium influx stimulates mitochondrial metabolism and initiates proliferation in hematopoietic stem cells (HSCs). Extracellular adenosine, sourced from surrounding hematopoietic progenitors, inhibits this calcium influx, thereby suppressing mitochondrial metabolism and promoting HSC quiescence. This is the first demonstration that a calcium-mitochondria pathway regulates HSC division.

Keyphrases

stem cells
oxidative stress
bone marrow
signaling pathway
cell death
protein kinase
cell therapy
reactive oxygen species