Guanosine-based hydrogel as a supramolecular scaffold for template-assisted macrocyclization.

The G-quartet-like supramolecular assembly present in guanosine hydrogel templates macrocyclization between bis-azide and bis-alkyne fragments. The resulting macrocycle enhances viscoelastic properties, and strengthens the hydrogel network. This approach holds potential for the in situ synthesis of drugs and their simultaneous delivery in a stimuli-responsive manner.