Higher genetic risk loads confer more diverse manifestations and higher risk of lupus nephritis in systemic lupus erythematosus.

Young-Chang KwonEunji HaHyuk-Hee KwonDae Jin ParkJung-Min ShinYoung Bin JooWon Tae ChungDae-Hyun YooHye Soon Lee Kwangwoo Kim Sang-Cheol Bae So-Young Bang

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

The SLE patients with higher wGRS tended to have earlier onset-age, anti-Sm antibody, and more diverse clinical phenotypes. Genetic profiling may predict high risk for lupus nephritis and diverse clinical course in SLE patients.

Keyphrases

systemic lupus erythematosus
end stage renal disease
chronic kidney disease
ejection fraction
disease activity
newly diagnosed
prognostic factors
copy number
gene expression
patient reported