Unravelling blood-based epigenetic mechanisms: the impact of hsa-miR-146a and histone H3 acetylation in lead-induced inflammation among occupational workers.

Gangam Sai KiranPvsn Kiran KumarPrasenjit MitraKanishka KumarTaru GoyalShailja SharmaShweta RanaPraveen Sharma

Published in: International archives of occupational and environmental health (2023)

The finding that hsa-miR146a was significantly upregulated in individuals with high BLL and had a significant negative correlation with serum IL-6 suggests that Pb-induced oxidative stress likely activates H3 acetylation, which then releases inflammatory cytokines like IL-6.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
oxidative stress
dna methylation
diabetic rats
gene expression
high glucose
histone deacetylase
heavy metals
hydrogen peroxide
drug induced
nitric oxide
stress induced