Prognostic significance of chromosomal abnormalities at relapse in children with relapsed acute myeloid leukemia: A retrospective cohort study of the Relapsed AML 2001/01 Study.

Kim KleinH Berna BeverlooMartin ZimmermannSusana C RaimondiChristine von NeuhoffValérie de HaasRomy Elise van WeelderenJacqueline CloosJonas AbrahamssonYves BertrandMichael DworzakAlcira FynnBrenda GibsonShau-Yin HaChristine J HarrisonHenrik HasleSarah ElitzurGuy LevergerAlexey A MaschanBassem RazzoukDirk ReinhardtCarmelo RizzariPter SmisekUrsula CreutzigGertjan J L Kaspers

Published in: Pediatric blood & cancer (2021)

The cytogenetic subgroup at relapse is an independent risk factor for (event-free) survival. Cytogenetic assessment at the time of relapse is of high importance and may contribute to improved risk-adapted treatment for children with relapsed AML.

Keyphrases

acute myeloid leukemia
free survival
allogeneic hematopoietic stem cell transplantation
young adults
acute lymphoblastic leukemia
diffuse large b cell lymphoma
hodgkin lymphoma
multiple myeloma
copy number
clinical trial
phase iii
replacement therapy