Effects of a topical treatment with spleen tyrosine kinase inhibitor in healthy subjects and patients with cold urticaria or chronic spontaneous urticaria: Results of a phase 1a/b randomised double-blind placebo-controlled study.
Marion C DicksonAlexandra WalkerClive GrattanHayley PerryNicola WilliamsNirav RatiaOdile DewitSophie GisbertMartin MetzMarcus MaurerPublished in: British journal of clinical pharmacology (2021)
This Phase 1/1b study confirms that GSK2646264 cream applied topically penetrates the skin and some reduction in CTT was observed. (NCT02424799).