Histone deacetylase (HDAC) inhibitors- based drugs are effective to control Mycobacterium tuberculosis infection and promote the sensibility for rifampicin in MDR strain.

Adrián Rodríguez-CarlosYolanda Jacobo-DelgadoAlan Orlando Santos-MenaMariana H García-HernándezLuis Adrian De Jesus-GonzalezEdgar E Lara-RamirezBruno Rivas-Santiago

Published in: Memorias do Instituto Oswaldo Cruz (2023)

Our data support the usefulness of in silico approaches for drug repositioning to provide a potential adjunctive therapy for TB.

Keyphrases

histone deacetylase
mycobacterium tuberculosis
pulmonary tuberculosis
multidrug resistant
electronic health record
molecular docking
drug induced
big data
adverse drug
human health
machine learning
climate change