Regulation of Hematopoietic Stem Cell Fate and Malignancy.
Hee Jun ChoJungwoon LeeSuk Ran YoonHee Gu LeeHaiyoung JungPublished in: International journal of molecular sciences (2020)
The regulation of hematopoietic stem cell (HSC) fate decision, whether they keep quiescence, self-renew, or differentiate into blood lineage cells, is critical for maintaining the immune system throughout one's lifetime. As HSCs are exposed to age-related stress, they gradually lose their self-renewal and regenerative capacity. Recently, many reports have implicated signaling pathways in the regulation of HSC fate determination and malignancies under aging stress or pathophysiological conditions. In this review, we focus on the current understanding of signaling pathways that regulate HSC fate including quiescence, self-renewal, and differentiation during aging, and additionally introduce pharmacological approaches to rescue defects of HSC fate determination or hematopoietic malignancies by kinase signaling pathways.
Keyphrases
- hematopoietic stem cell
- signaling pathway
- induced apoptosis
- pi k akt
- stem cells
- cell cycle arrest
- mesenchymal stem cells
- epithelial mesenchymal transition
- solid phase extraction
- endoplasmic reticulum stress
- single cell
- bone marrow
- molecularly imprinted
- oxidative stress
- cell death
- heat stress
- mass spectrometry
- decision making
- liquid chromatography