Pitx2c inhibition increases atrial fibroblast activity: Implications in atrial arrhythmogenesis.

Yu-Hsun KaoCheng-Chih ChungWan-Li ChengBaigalmaa LkhagvaYi-Jen Chen

Published in: European journal of clinical investigation (2019)

These findings suggest that downregulation of Pitx2c may regulate atrial fibrosis through modulating calcium homeostasis, which may contribute to its role in anti-atrial fibrosis, and Pitx2c downregulation may change the atrial electrophysiology and AF occurrence through modulating fibroblast activity.

Keyphrases

atrial fibrillation
left atrial
catheter ablation
signaling pathway
cell proliferation
risk assessment
left ventricular