Antinociceptive effect of natural and synthetic alkamides involves TRPV1 receptors.

Vianey de la Rosa-LugoMacdiel Acevedo-QuirozMyrna Deciga-CamposMaría Yolanda Rios

Published in: The Journal of pharmacy and pharmacology (2017)

These results suggest that alkamide affinin, longipinamide A, longipenamide A and longipenamide B isolated from Heliopsis longipes as well as the synthesized analogue compounds N-isobutyl-feruloylamide and N-isobutyl-dihydroferuloylamide produce their effects by activating TRPV1 receptor and they may have potential for the development of new analgesic drugs for the treatment of orofacial pain.

Keyphrases

neuropathic pain
spinal cord
chronic pain
spinal cord injury
anti inflammatory
signaling pathway
pain management
climate change
risk assessment
replacement therapy