DPSCs treated by TGF-β1 regulate angiogenic sprouting of three-dimensionally co-cultured HUVECs and DPSCs through VEGF-Ang-Tie2 signaling.

Yuchen ZhangJunqing LiuTing ZouYubingqing QiBaicheng YiWaruna Lakmal DissanayakaCheng Fei Zhang

Published in: Stem cell research & therapy (2021)

This study revealed that TGF-β1 can induce DPSC differentiation into functional pericyte-like cells. T-DPSCs maintain vessel stability through Ang1/Tie2 and VEGF/VEGFR2 signaling.

Keyphrases

vascular endothelial growth factor
endothelial cells
angiotensin ii
transforming growth factor
blood brain barrier
single cell
epithelial mesenchymal transition