Angiogenic imbalance in pre-eclampsia and fetal growth restriction: enhanced soluble Fms-like tyrosine kinase-1 binding or diminished production of placental growth factor?

Anna C M KluiversA BiesbroekW VisserLangeza SalehH RusscherJ A H DanserRugina I Neuman

Published in: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2022)

Particularly in pregnancies with early-onset PE and SGA, diminished PlGF production is an important cause of low free PlGF levels. Under such conditions, sFlt-1 lowering is unlikely to restore the angiogenic imbalance. This article is protected by copyright. All rights reserved.

Keyphrases

tyrosine kinase
early onset
growth factor
epidermal growth factor receptor
late onset
preterm birth
gestational age
pregnant women
pregnancy outcomes
binding protein