Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT1A receptor-mediated suppression of nausea and anxiety in rats.

Roger G PertweeErin M RockKelsey GuentherCheryl L LimebeerLesley A StevensonChristeene HajReem SmoumLinda A ParkerRaphael Mechoulam

Published in: British journal of pharmacology (2017)

HU-580 is more potent than CBDA at enhancing 5-HT1A receptor activation, and inhibiting signs of acute and anticipatory nausea, and anxiety. Consequently, HU-580 is a potential medicine for treating some nausea and anxiety disorders and possibly other disorders ameliorated by enhancement of 5-HT1A receptor activation.

Keyphrases

chemotherapy induced
liver failure
sleep quality
respiratory failure
binding protein
intensive care unit
climate change
depressive symptoms
physical activity
human health