Antithrombin plus alpha-1 protease inhibitor does not affect coagulation and inflammation in two murine models of acute lung injury.

Jenny JuschtenSarah Anne IngelseMartinus Adrianus Wilhelmus MaasArmand Roelof Johan GirbesNicole Petra JuffermansMarcus Josephus SchultzPieter Roel Tuinman

Published in: Intensive care medicine experimental (2019)

In two different murine models of acute lung injury, neither single therapy with AT or A1PI nor combination of both agents attenuates the pronounced pulmonary coagulation or inflammatory response.

Keyphrases

lipopolysaccharide induced
inflammatory response
lps induced
toll like receptor
oxidative stress
pulmonary hypertension
immune response
bone marrow