In silico enhancer mining reveals SNS-032 and EHMT2 inhibitors as therapeutic candidates in high-grade serous ovarian cancer.
Marcos QuintelaDavid W JamesJetzabel GarciaKadie EdwardsLavinia MargaritNagindra DasKerryn Lutchman-SinghAmy L BeynonInmaculada RiojaRab K PrinjhaNicola R HarkerDeyarina GonzalezRobert Steven ConlanLewis W FrancisPublished in: British journal of cancer (2023)
Here, we report the first attempt to exploit ovarian cancer epigenomic landscapes for drug discovery. This computational pipeline holds enormous potential for translating epigenomic profiling into therapeutic leads.