Post-operative radiotherapy in adenoid cystic carcinoma of salivary glands versus surgery alone: what is the evidence about survival and local control? A systematic review and meta-analysis.
Alfonso ScarpaPasquale ViolaMassimo RalliFederico Maria GioacchiniGiovanni SalzanoArianna Di StadioClaudia CassandroGiuseppe ChiarellaFilippo RicciardielloPietro De LucaFrancesco Antonio SalzanoEmilio AvallonePublished in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2023)
The findings from the meta-analysis suggest that post-operative radiotherapy significantly improves local control in patients with adenoid cystic carcinoma. However, there was no statistically significant increase in survival at 5 and 10 years. It is essential to note that the quality of the studies included in this meta-analysis ranged from fair to poor. To better clarify the indications for post-operative radiotherapy, future high-quality research is needed, particularly with improved stratification of patient groups. Additionally, it is important to recognize that achieving local control in adenoid cystic carcinoma is crucial for enhancing the overall quality of life for patients. We acknowledge that this review was not registered in the PROSPERO database, and the data pooling was conducted using a random effects model.
Keyphrases
- systematic review
- early stage
- locally advanced
- case control
- end stage renal disease
- radiation therapy
- radiation induced
- meta analyses
- newly diagnosed
- minimally invasive
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- emergency department
- squamous cell carcinoma
- big data
- coronary artery bypass
- coronary artery disease
- acute coronary syndrome
- patient reported outcomes
- machine learning
- artificial intelligence