Rapid, simple, and economical LC-MS/MS method for simultaneous determination of ceftazidime and avibactam in human plasma and its application in therapeutic drug monitoring.
Yu ChengMaohua ChenBingqing ZhangHailin LinXueyong LiYipeng CaiHui ZhangWancai QueMaobai LiuHong-Qiang QiuPublished in: Journal of clinical pharmacy and therapeutics (2022)
A robust, rapid, simple, and economical LC-MS/MS method for the simultaneous determination of CAZ and AVI was developed. The considerable PK variability of CAZ/AVI among patients demonstrates the clinical significance of TDM.
Keyphrases
- simultaneous determination
- liquid chromatography tandem mass spectrometry
- tandem mass spectrometry
- high performance liquid chromatography
- liquid chromatography
- ultra high performance liquid chromatography
- loop mediated isothermal amplification
- solid phase extraction
- gram negative
- klebsiella pneumoniae
- mass spectrometry
- high resolution mass spectrometry
- gas chromatography
- high resolution